RESEARCH ADVANCES IN THE ASSOCIATION BETWEEN GESTATIONAL DIABETES MELLITUS AND HYPERTENSIVE DI-SORDER COMPLICATING PREGNANCY

Abstract

Gestational diabetes mellitus (GDM) and hypertensive disorder complicating pregnancy (HDCP) are common complications during pregnancy, and the probability of HDCP is as high as 25%-32% in pregnant women with GDM. GDM and HDCP are interrelated from the aspects of high-risk factors, pathogenesis, and impact on maternal and fetal outcome. The common high-risk factors for GDM and HDCP include dyslipidemia, pregnancy infection, smoking, old age, and psychological abnormality, and their common pathogenesis includes insulin resistance, inflammatory factors, and the release of Afamin. GDM and HDCP are often accompanied by thyroid diseases during pregnancy, which may lead to adverse maternal and fetal outcome, such as premature rupture of membranes, cesarean section, fetal distress, stillbirth, neonatal asphyxia, and neonatal malformation. This article mainly discusses and analyzes the association between GDM and HDCP, in order to improve the awareness of these two diseases among clinicians and their treatment outcomes.

Keywords

• gestational diabetes mellitus|hypertensive disorder complicating pregnancy|pregnancy complications|risk factors|insulin resistance|inflammation|cytokines|review