Frontiers in Oncology (Sep 2024)
Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond
- Analiz Rodriguez,
- Manmeet S. Ahluwalia,
- Chetan Bettegowda,
- Henry Brem,
- Bob S. Carter,
- Susan Chang,
- Sunit Das,
- Charles Eberhart,
- Tomas Garzon-Muvdi,
- Costas G. Hadjipanayis,
- Cynthia Hawkins,
- Thomas S. Jacques,
- Alexander A. Khalessi,
- Michael W. McDermott,
- Tom Mikkelsen,
- Brent A. Orr,
- Joanna J. Phillips,
- Joanna J. Phillips,
- Mark Rosenblum,
- William J. Shelton,
- David A. Solomon,
- Andreas von Deimling,
- Graeme F. Woodworth,
- James T. Rutka
Affiliations
- Analiz Rodriguez
- Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States
- Manmeet S. Ahluwalia
- Department of Medical Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, United States
- Chetan Bettegowda
- Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, United States
- Henry Brem
- Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, United States
- Bob S. Carter
- Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
- Susan Chang
- Division of Neuro-Oncology, Department of Neurosurgery, University of California San Francisco, San Francisco, CA, United States
- Sunit Das
- Division of Neurosurgery, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada
- Charles Eberhart
- Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Tomas Garzon-Muvdi
- Department of Neurosurgery, Emory University, Atlanta, GA, United States
- Costas G. Hadjipanayis
- Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
- Cynthia Hawkins
- 0Division of Pathology, Hospital for Sick Children, Toronto, ON, Canada
- Thomas S. Jacques
- 1Developmental Biology and Cancer Programme, UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom
- Alexander A. Khalessi
- 2Department of Radiology and Neurosciences, Don and Karen Cohn Chancellor’s Endowed Chair of Neurological Surgery, University of California, San Diego, San Diego, CA, United States
- Michael W. McDermott
- 3Division of Neurosurgery, Miami Neuroscience Institute, Miami, FL, United States
- Tom Mikkelsen
- 4Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI, United States
- Brent A. Orr
- 5Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, United States
- Joanna J. Phillips
- 6Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States
- Joanna J. Phillips
- 7Neuropathology Division, Department of Pathology, University of California, San Francisco, San Francisco, CA, United States
- Mark Rosenblum
- 8Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI, United States
- William J. Shelton
- Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States
- David A. Solomon
- 9Division of Neuropathology, Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States
- Andreas von Deimling
- 0Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany
- Graeme F. Woodworth
- 1Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States
- James T. Rutka
- 2Division of Neurosurgery, Chair Emeritus, Hospital for Sick Children, Toronto, ON, Canada
- DOI
- https://doi.org/10.3389/fonc.2024.1471257
- Journal volume & issue
-
Vol. 14
Abstract
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently recommendations on intraoperative tissue procurement only exist for diffuse gliomas but management of other brain tumor subtypes can also benefit from these protocols. Fresh tissue from surgical resection can now be used for intraoperative diagnostics and functional precision medicine assays. A multidisciplinary neuro-oncology perspective is critical to develop the best avenues for practical standardization. This perspective from the multidisciplinary Oncology Tissue Advisory Board (OTAB) discusses current advances, future directions, and the imperative of adopting standardized protocols for diverse brain tumor entities. There is a growing need for consistent operating room practices to enhance patient care, streamline research efforts, and optimize outcomes.
Keywords