Frontiers in Oncology (Sep 2024)

Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond

  • Analiz Rodriguez,
  • Manmeet S. Ahluwalia,
  • Chetan Bettegowda,
  • Henry Brem,
  • Bob S. Carter,
  • Susan Chang,
  • Sunit Das,
  • Charles Eberhart,
  • Tomas Garzon-Muvdi,
  • Costas G. Hadjipanayis,
  • Cynthia Hawkins,
  • Thomas S. Jacques,
  • Alexander A. Khalessi,
  • Michael W. McDermott,
  • Tom Mikkelsen,
  • Brent A. Orr,
  • Joanna J. Phillips,
  • Joanna J. Phillips,
  • Mark Rosenblum,
  • William J. Shelton,
  • David A. Solomon,
  • Andreas von Deimling,
  • Graeme F. Woodworth,
  • James T. Rutka

DOI
https://doi.org/10.3389/fonc.2024.1471257
Journal volume & issue
Vol. 14

Abstract

Read online

Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently recommendations on intraoperative tissue procurement only exist for diffuse gliomas but management of other brain tumor subtypes can also benefit from these protocols. Fresh tissue from surgical resection can now be used for intraoperative diagnostics and functional precision medicine assays. A multidisciplinary neuro-oncology perspective is critical to develop the best avenues for practical standardization. This perspective from the multidisciplinary Oncology Tissue Advisory Board (OTAB) discusses current advances, future directions, and the imperative of adopting standardized protocols for diverse brain tumor entities. There is a growing need for consistent operating room practices to enhance patient care, streamline research efforts, and optimize outcomes.

Keywords