IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

Daniele C. Nascimento; Paulo H. Melo; Annie R. Piñeros; Raphael G. Ferreira; David F. Colón; Paula B. Donate; Fernanda V. Castanheira; Aline Gozzi; Paula G. Czaikoski; Wanda Niedbala; Marcos C. Borges; Dario S. Zamboni; Foo Y. Liew; Fernando Q. Cunha; Jose C. Alves-Filho

doi:10.1038/ncomms14919

Nature Communications (Apr 2017)

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

Daniele C. Nascimento,
Paulo H. Melo,
Annie R. Piñeros,
Raphael G. Ferreira,
David F. Colón,
Paula B. Donate,
Fernanda V. Castanheira,
Aline Gozzi,
Paula G. Czaikoski,
Wanda Niedbala,
Marcos C. Borges,
Dario S. Zamboni,
Foo Y. Liew,
Fernando Q. Cunha,
Jose C. Alves-Filho

Affiliations

Daniele C. Nascimento: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Paulo H. Melo: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Annie R. Piñeros: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Raphael G. Ferreira: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
David F. Colón: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Paula B. Donate: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Fernanda V. Castanheira: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Aline Gozzi: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo
Paula G. Czaikoski: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Wanda Niedbala: Department of Immunology, Institute of Infection, Immunity and Inflammation, University of Glasgow
Marcos C. Borges: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo
Dario S. Zamboni: Departments of Cell Biology and Microbial Pathogenesis, Ribeirao Preto Medical School, University of Sao Paulo
Foo Y. Liew: Department of Immunology, Institute of Infection, Immunity and Inflammation, University of Glasgow
Fernando Q. Cunha: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo
Jose C. Alves-Filho: Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo

DOI: https://doi.org/10.1038/ncomms14919
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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