Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

Abstract

Xiaojuan Li,1 Tiewei Li,1 Jingjing Wang,2 Yichuan Feng,1 Chong Ren,1 Zhe Xu,1 Junmei Yang,1 Qian Zhang,3 Caiyan An4 1Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, 450018, People’s Republic of China; 2Department of Neonatology, Ordos Central Hospital, Ordos, 01700, People’s Republic of China; 3The Center for New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot, People’s Republic of China; 4Clinical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, People’s Republic of ChinaCorrespondence: Tiewei LiZhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33M Waihuan East Road, Longhu, Zhengzhou, 450018, People’s Republic of ChinaTel [phone]Email [email protected] WangOrdos Central Hospital, No. 23, Yijinholo Street, Dongsheng District, Ordos, 017000, People’s Republic of ChinaTel [phone]Email [email protected]: C-reactive protein (CRP) level and platelet (PLT) count have been demonstrated to be independent risk factor for neonatal sepsis. However, no data is currently available in regarding the association between CRP-to-PLT ratio (CPR) and neonatal sepsis.Methods: A total of 1048 neonates with suspected sepsis were enrolled in this study. Complete clinical and laboratory data were collected. CPR was calculated as CRP (mg/L)/PLT (107 cells/L). Multivariate logistic regression analysis was performed to identify the potential independent risk factors of neonatal sepsis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CPR in predicting neonatal sepsis.Results: Neonates with sepsis had a higher CPR. CPR also showed a gradual increase in the infection, mild sepsis and severe sepsis groups. Multivariate analysis revealed that CPR was a significant independent predictor of the presence of neonatal sepsis (odds ratio [OR], 1.015; 95% confidence interval [CI], 1.008– 1.022, P < 0.001) and severe sepsis (OR, 1.002; 95% CI, 1.000– 1.003, P = 0.007). ROC curve revealed showed that CPR had a well-discriminatory power in predicting sepsis (area under curve [AUC], 0.68; 95% CI, 0.65– 0.72, P < 0.001) and severe sepsis (AUC, 0.68; 95% CI, 0.65– 0.72, P < 0.001).Conclusion: The present study demonstrated that a higher CPR is an independent predictor of the presence and severity of neonatal sepsis.Keywords: C-reactive protein-to-platelet ratio, neonatal sepsis, risk factor, severe sepsis

Keywords

• c-reactive protein-to-platelet ratio
• neonatal sepsis
• risk factor
• severe sepsis