Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine

Toru Nakata; Hiromichi Shimizu; Sayaka Nagata; Go Ito; Satoru Fujii; Kohei Suzuki; Ami Kawamoto; Fumiaki Ishibashi; Reiko Kuno; Sho Anzai; Tatsuro Murano; Tomohiro Mizutani; Shigeru Oshima; Kiichiro Tsuchiya; Tetsuya Nakamura; Katsuto Hozumi; Mamoru Watanabe; Ryuichi Okamoto

doi:10.1016/j.dib.2016.12.045

Data in Brief (Feb 2017)

Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine

Toru Nakata,
Hiromichi Shimizu,
Sayaka Nagata,
Go Ito,
Satoru Fujii,
Kohei Suzuki,
Ami Kawamoto,
Fumiaki Ishibashi,
Reiko Kuno,
Sho Anzai,
Tatsuro Murano,
Tomohiro Mizutani,
Shigeru Oshima,
Kiichiro Tsuchiya,
Tetsuya Nakamura,
Katsuto Hozumi,
Mamoru Watanabe,
Ryuichi Okamoto

Affiliations

Toru Nakata: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Hiromichi Shimizu: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Sayaka Nagata: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Go Ito: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Satoru Fujii: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Kohei Suzuki: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Ami Kawamoto: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Fumiaki Ishibashi: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Reiko Kuno: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Sho Anzai: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Tatsuro Murano: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Tomohiro Mizutani: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Shigeru Oshima: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Kiichiro Tsuchiya: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Tetsuya Nakamura: Department of Advanced Therapeutics in GI Diseases, Tokyo Medical and Dental University, Tokyo, Japan
Katsuto Hozumi: Department of Immunology, Tokai University School of Medicine, Isehara, Japan
Mamoru Watanabe: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Ryuichi Okamoto: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

DOI: https://doi.org/10.1016/j.dib.2016.12.045
Journal volume & issue: Vol. 10, no. C
pp. 551 – 556

Abstract

Read online

The data on the immunohistochemical analysis of conditional Notch ligand knockout mice is presented. Targeted deletion of Jag1, Dll1, Dll4, or Dll1 plus Dll4 in Lgr5+ve cells was induced by a Cre-mediated gene recombination, and differentiation or proliferation of the intestinal epithelial cells was examined by immunohistochemistry. These data are the extension of the data presented and discussed in the paper entitled “Indispensable role of non-canonical Notch signaling in the proliferation of Apc-deficient intestinal tumors“ (Nakata et al., Submitted for publication) [1].

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

About the journal