A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides

Matthew L. Clarke; Marcia B. France; Jose A. Fuentes; Edward J. Milton; Geoffrey J. Roff

doi:10.1186/1860-5397-3-18

Beilstein Journal of Organic Chemistry (May 2007)

A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides

Matthew L. Clarke,
Marcia B. France,
Jose A. Fuentes,
Edward J. Milton,
Geoffrey J. Roff

Affiliations

Matthew L. Clarke: School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK
Marcia B. France: Department of Chemistry, Washington and Lee University, Lexington, VA 24450, USA
Jose A. Fuentes: School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK
Edward J. Milton: School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK
Geoffrey J. Roff: School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK

DOI: https://doi.org/10.1186/1860-5397-3-18
Journal volume & issue: Vol. 3, no. 1
p. 18

Abstract

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A convenient microwave accelerated cross-coupling procedure between aryl chlorides with a range of boronic acids has been developed. An explanation for the low reactivity of highly fluorinated boronic acids in Suzuki coupling is provided.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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