Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

Subbarayalu Panneerdoss; Suryavathi Viswanadhapalli; Nourhan Abdelfattah; Benjamin C. Onyeagucha; Santosh Timilsina; Tabrez A. Mohammad; Yidong Chen; Michael Drake; Kristiina Vuori; T. Rajendra Kumar; Manjeet K. Rao

doi:10.1038/s41467-017-00590-9

Nature Communications (Sep 2017)

Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

Subbarayalu Panneerdoss,
Suryavathi Viswanadhapalli,
Nourhan Abdelfattah,
Benjamin C. Onyeagucha,
Santosh Timilsina,
Tabrez A. Mohammad,
Yidong Chen,
Michael Drake,
Kristiina Vuori,
T. Rajendra Kumar,
Manjeet K. Rao

Affiliations

Subbarayalu Panneerdoss: Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio
Suryavathi Viswanadhapalli: Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio
Nourhan Abdelfattah: Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio
Benjamin C. Onyeagucha: Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio
Santosh Timilsina: Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio
Tabrez A. Mohammad: Greehey Children’s Cancer Research Institute 8403 Floyd Curl Drive, University of Texas Health Science Center at San Antonio
Yidong Chen: Greehey Children’s Cancer Research Institute 8403 Floyd Curl Drive, University of Texas Health Science Center at San Antonio
Michael Drake: Department of Laboratory Animal Resources, University of Texas Health Science Center at San Antonio
Kristiina Vuori: Sanford-Burnham Medical Research Institute
T. Rajendra Kumar: Department of Obstetrics and Gynecology, University of Colorado Denver
Manjeet K. Rao: Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio

DOI: https://doi.org/10.1038/s41467-017-00590-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogenesis, little of the mechanism is known. Here the authors show that Sertoli cells employ LC3-associated phagocytosis (LAP) by recruiting autophagy member proteins to clear apoptotic germ cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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