Современная онкология (Dec 2014)
Features of development of metachronous and synchronous tumors in the population of Belgorod region associated with the consequences of the Chernobyl accident
Abstract
The analysis of the prevalence of primary multiple malignant neoplasms (PMMN) in the Belgorod region (BR), one of the 14 regions ofRussia, officially referred to the victims of the Chernobyl radiation accident in 1986. The incidence of metachronous and synchronoustumors in the composition of PMMN was analyzed in the dynamics of the five-year observation periods. It is established that during the first four observation periods (1981-1985, 1986-1990, 1991-1995, 1996-2000) were recorded mainly PMMN with metachronous development. Moreover, before the emergency period (1981-1985) and in the first ten years after the accident (1986-1995) the emergence of second tumors was observed mainly after 10 or more years after treatment of the first tumor. In subsequent periods, including 1996-2010, the timing of detection of the second and subsequent metachronous tumors after treatment of the first tumor was reduced on average by 5-10 years. In 2001-2010 the vast majority of newly diagnosed preneoplasia had synchronous character development. It can be assumed that the peculiarities of the formation PMMN in the population BR, with the predominant development of synchronous tumors in 2001-2010 (15 years after the accident), can be caused by the reduction in biological latent period metachronous tumors, as a result of the remote effects of low doses of radiation due to the Chernobyl accident.
