m5C modification of mRNA serves a DNA damage code to promote homologous recombination

Hao Chen; Haibo Yang; Xiaolan Zhu; Tribhuwan Yadav; Jian Ouyang; Samuel S. Truesdell; Jun Tan; Yumin Wang; Meihan Duan; Leizhen Wei; Lee Zou; Arthur S. Levine; Shobha Vasudevan; Li Lan

doi:10.1038/s41467-020-16722-7

Nature Communications (Jun 2020)

m5C modification of mRNA serves a DNA damage code to promote homologous recombination

Hao Chen,
Haibo Yang,
Xiaolan Zhu,
Tribhuwan Yadav,
Jian Ouyang,
Samuel S. Truesdell,
Jun Tan,
Yumin Wang,
Meihan Duan,
Leizhen Wei,
Lee Zou,
Arthur S. Levine,
Shobha Vasudevan,
Li Lan

Affiliations

Hao Chen: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
Haibo Yang: Massachusetts General Hospital Cancer Center, Harvard Medical School
Xiaolan Zhu: Massachusetts General Hospital Cancer Center, Harvard Medical School
Tribhuwan Yadav: Department of Pathology, Massachusetts General Hospital, Harvard Medical School
Jian Ouyang: Massachusetts General Hospital Cancer Center, Harvard Medical School
Samuel S. Truesdell: Massachusetts General Hospital Cancer Center, Harvard Medical School
Jun Tan: Massachusetts General Hospital Cancer Center, Harvard Medical School
Yumin Wang: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
Meihan Duan: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
Leizhen Wei: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
Lee Zou: Massachusetts General Hospital Cancer Center, Harvard Medical School
Arthur S. Levine: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
Shobha Vasudevan: Massachusetts General Hospital Cancer Center, Harvard Medical School
Li Lan: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine

DOI: https://doi.org/10.1038/s41467-020-16722-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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