Theoretical study of 47Sc production for theranostic applications using proton beams on enriched titanium targets

Abstract

Recently, scandium-47 has attracted attention in the scientific community thanks to its promising features, making it suitable for targeted radiotherapy and theranostic applications, also in combination with the β+ emitters 43Sc/44Sc. However, in view of possible pre-clinical and clinical studies, finding efficient production routes is still a current research topic. In this work we investigate 47Sc cyclotron production using proton beams on enriched titanium targets. The analysis of the cross sections and yields of both 47Sc (T1/2 = 3.35 d) and its main contaminant 46Sc (T1/2 = 83.79 d) has been performed with the nuclear reaction code Talys (v.1.95). The experimental data (scarce and relatively old) are compared with model calculations and some discrepancies emerge even after the tuning of parameters defining the nuclear level densities, involved in the compound nucleus formation. The 49Ti case allows a more precise cross sections reproduction, conversely the 50Ti case requires further theoretical investigations. Preliminary yields analysis has been carried out for both 47Sc and 46Sc.