Nature Communications (Jun 2020)

FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome

  • Xiaoqin Zhan,
  • Hadhimulya Asmara,
  • Ning Cheng,
  • Giriraj Sahu,
  • Eduardo Sanchez,
  • Fang-Xiong Zhang,
  • Gerald W. Zamponi,
  • Jong M. Rho,
  • Ray W. Turner

DOI
https://doi.org/10.1038/s41467-020-16250-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce elevated levels of activity in Fmr1 KO mice.