NUP-98 Rearrangements Led to the Identification of Candidate Biomarkers for Primary Induction Failure in Pediatric Acute Myeloid Leukemia

Vincenza Barresi; Virginia Di Bella; Nellina Andriano; Anna Provvidenza Privitera; Paola Bonaccorso; Manuela La Rosa; Valeria Iachelli; Giorgia Spampinato; Giulio Pulvirenti; Chiara Scuderi; Daniele F. Condorelli; Luca Lo Nigro

doi:10.3390/ijms22094575

International Journal of Molecular Sciences (Apr 2021)

NUP-98 Rearrangements Led to the Identification of Candidate Biomarkers for Primary Induction Failure in Pediatric Acute Myeloid Leukemia

Vincenza Barresi,
Virginia Di Bella,
Nellina Andriano,
Anna Provvidenza Privitera,
Paola Bonaccorso,
Manuela La Rosa,
Valeria Iachelli,
Giorgia Spampinato,
Giulio Pulvirenti,
Chiara Scuderi,
Daniele F. Condorelli,
Luca Lo Nigro

Affiliations

Vincenza Barresi: Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy
Virginia Di Bella: Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy
Nellina Andriano: Cytogenetic-Cytofluorimetric-Molecular Biology Lab, 95123 Catania, Italy
Anna Provvidenza Privitera: Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy
Paola Bonaccorso: Cytogenetic-Cytofluorimetric-Molecular Biology Lab, 95123 Catania, Italy
Manuela La Rosa: Cytogenetic-Cytofluorimetric-Molecular Biology Lab, 95123 Catania, Italy
Valeria Iachelli: Cytogenetic-Cytofluorimetric-Molecular Biology Lab, 95123 Catania, Italy
Giorgia Spampinato: Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy
Giulio Pulvirenti: Cytogenetic-Cytofluorimetric-Molecular Biology Lab, 95123 Catania, Italy
Chiara Scuderi: Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy
Daniele F. Condorelli: Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy
Luca Lo Nigro: Cytogenetic-Cytofluorimetric-Molecular Biology Lab, 95123 Catania, Italy

DOI: https://doi.org/10.3390/ijms22094575
Journal volume & issue: Vol. 22, no. 9
p. 4575

Abstract

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Conventional chemotherapy for acute myeloid leukemia regimens generally encompass an intensive induction phase, in order to achieve a morphological remission in terms of bone marrow blasts (SPINK2, TMA7, SPCS2, CDCP1, CAPZA1, FGFR1OP2, MAN1A2, NT5C3A and SRP54. In conclusion, the integrated analysis of NUP98 mutational analysis and transcriptome profiles allowed the identification of novel putative biomarkers for the prediction of PIF in AML.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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