Nature Communications (Aug 2020)

Blood substitution therapy rescues the brain of mice from ischemic damage

  • Xuefang Ren,
  • Heng Hu,
  • Imran Farooqi,
  • James W. Simpkins

DOI
https://doi.org/10.1038/s41467-020-17930-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.