Quantitative analysis of peripapillary capillary volume using dense B-scan OCT angiography in normal and diabetic retina

Abstract

Abstract Background The value of quantitatively analyzing peripapillary capillary volume (PPCV) distribution was explored in normal and diabetic retinopathy (DR) eyes using dense B-scan optical coherence tomography angiography (DB OCTA). Methods This was a cross-sectional observational study followed by prospective follow-up for those with DR, which enrolled 101 healthy subjects and 140 DR patients. Dense, automatic, real-time (DART) volume scans of DB OCTA were performed using a Spectralis HRA + OCT2. ImageJ and MATLAB were used to process and calculate PPCV distribution detected by DB OCTA. Results In normal subjects, PPCV distribution were significantly correlated with the age and quadrant location (all P 0.05). The PPCV distribution is significantly correlated with post-treatment best-corrected visual acuity in both the pan-retinal photocoagulation treatment and surgery groups (all P < 0.003) but not in the anti-VEGF treatment group (P = 0.940). Conclusions Quantitative assessment of PPCV distribution using DB OCTA is valuable in prognosis evaluation of DR with pan-retinal photocoagulation and surgery.

Keywords

• Dense B-scan optical coherence tomography angiography
• Peripapillary capillary volume
• Diabetic retinopathy