Redefining GBA gene structure unveils the ability of Cap-independent, IRES-dependent gene regulation

Keiko Miyoshi; Hiroko Hagita; Taigo Horiguchi; Ayako Tanimura; Takafumi Noma

doi:10.1038/s42003-022-03577-5

Communications Biology (Jul 2022)

Redefining GBA gene structure unveils the ability of Cap-independent, IRES-dependent gene regulation

Keiko Miyoshi,
Hiroko Hagita,
Taigo Horiguchi,
Ayako Tanimura,
Takafumi Noma

Affiliations

Keiko Miyoshi: Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences
Hiroko Hagita: Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences
Taigo Horiguchi: Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences
Ayako Tanimura: Division of Food & Health Sciences, Department of Environmental and Symbiotic Sciences, Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
Takafumi Noma: Department of Nutrition and Health Promotion, Faculty of Human Life Studies, Hiroshima Jogakuin University

DOI: https://doi.org/10.1038/s42003-022-03577-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

The cell type-specific expression of the glucocerebrosidase gene, associated with the lysosomal storage disorder called Gaucher disease, is linked to cis- and trans-regulatory transcriptional and translational mechanisms.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal