Nature Communications (Jun 2021)
Maternal iron deficiency perturbs embryonic cardiovascular development in mice
- Jacinta I. Kalisch-Smith,
- Nikita Ved,
- Dorota Szumska,
- Jacob Munro,
- Michael Troup,
- Shelley E. Harris,
- Helena Rodriguez-Caro,
- Aimée Jacquemot,
- Jack J. Miller,
- Eleanor M. Stuart,
- Magda Wolna,
- Emily Hardman,
- Fabrice Prin,
- Eva Lana-Elola,
- Rifdat Aoidi,
- Elizabeth M. C. Fisher,
- Victor L. J. Tybulewicz,
- Timothy J. Mohun,
- Samira Lakhal-Littleton,
- Sarah De Val,
- Eleni Giannoulatou,
- Duncan B. Sparrow
Affiliations
- Jacinta I. Kalisch-Smith
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Nikita Ved
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Dorota Szumska
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Jacob Munro
- Victor Chang Cardiac Research Institute, Molecular, Structural and Computational Biology Division
- Michael Troup
- Victor Chang Cardiac Research Institute, Molecular, Structural and Computational Biology Division
- Shelley E. Harris
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Helena Rodriguez-Caro
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Aimée Jacquemot
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Jack J. Miller
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Eleanor M. Stuart
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Magda Wolna
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Emily Hardman
- Heart Development Laboratory, The Francis Crick Institute
- Fabrice Prin
- Heart Development Laboratory, The Francis Crick Institute
- Eva Lana-Elola
- Immune Cell Biology and Down Syndrome Laboratory, The Francis Crick Institute
- Rifdat Aoidi
- Immune Cell Biology and Down Syndrome Laboratory, The Francis Crick Institute
- Elizabeth M. C. Fisher
- Institute of Neurology, University College London
- Victor L. J. Tybulewicz
- Immune Cell Biology and Down Syndrome Laboratory, The Francis Crick Institute
- Timothy J. Mohun
- Heart Development Laboratory, The Francis Crick Institute
- Samira Lakhal-Littleton
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Sarah De Val
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- Eleni Giannoulatou
- Victor Chang Cardiac Research Institute, Molecular, Structural and Computational Biology Division
- Duncan B. Sparrow
- Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-021-23660-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects.
