Journal of the Saudi Heart Association (Oct 2017)

Gerbode defect: A comprehensive review of its history, anatomy, embryology, pathophysiology, diagnosis, and treatment

  • Erfanul Saker,
  • Ghazal N. Bahri,
  • Michael J. Montalbano,
  • Jaspreet Johal,
  • Rachel A. Graham,
  • Gabrielle G. Tardieu,
  • Marios Loukas,
  • R. Shane Tubbs

DOI
https://doi.org/10.1016/j.jsha.2017.01.006
Journal volume & issue
Vol. 29, no. 4
pp. 283 – 292

Abstract

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The purpose of this paper is to survey the literature on Gerbode defect and provide an overview of its history, anatomy, development, pathophysiology, diagnosis, and treatment options. The available literature on this topic, including case reports, was thoroughly reviewed. Gerbode defect is defined as abnormal shunting between the left ventricle and right atrium resulting from either a congenital defect or prior cardiac insults. The pathophysiology underlying the development of Gerbode defect is a disease process that injures the atrioventricular septum and leads to the abnormal shunting of blood. Although the most prevalent cause of Gerbode defect has historically been congenital, an increasing trend towards acquired cases has recently been reported owing to improved diagnostic capabilities and a greater number of invasive cardiac procedures. In conclusion, Gerbode defect is an increasingly recognized condition that warrants further study.

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