Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response

Dong-Jing Cai; Zi-Yu Zhang; Yue Bu; Li Li; Yue-Zhen Deng; Lun-Quan Sun; Cheng-Ping Hu; Min Li

doi:10.1038/s41419-022-05015-0

Cell Death and Disease (Jun 2022)

Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response

Dong-Jing Cai,
Zi-Yu Zhang,
Yue Bu,
Li Li,
Yue-Zhen Deng,
Lun-Quan Sun,
Cheng-Ping Hu,
Min Li

Affiliations

Dong-Jing Cai: Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University
Zi-Yu Zhang: Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University
Yue Bu: Department of Neurology, Xiangya Hospital, Central South University
Li Li: Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University
Yue-Zhen Deng: Xiangya Cancer Center, Xiangya Hospital, Central South University
Lun-Quan Sun: Xiangya Cancer Center, Xiangya Hospital, Central South University
Cheng-Ping Hu: Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University
Min Li: Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University

DOI: https://doi.org/10.1038/s41419-022-05015-0
Journal volume & issue: Vol. 13, no. 6
pp. 1 – 11

Abstract

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In the Wnt pathway, phosphorylation of GSK3β(S9) is very important to stabilize β-catenin complex, ASNS can upregulate phosphorylation of AKT on Ser473, then promote GSK3β phosphorylation on Ser9 to stabilize β-catenin complex. When Wnt pathway is activated, ASNS elevates p-DRP1(637) and decreases p-DRP1(616) to suppress mitochondrial fission.

Published in Cell Death and Disease

ISSN: 2041-4889 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Cytology
Website: http://www.nature.com/cddis/index.html

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