Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane

Marie-Lise Jobin; Sana Siddig; Zsombor Koszegi; Yann Lanoiselée; Vladimir Khayenko; Titiwat Sungkaworn; Christian Werner; Kerstin Seier; Christin Misigaiski; Giovanna Mantovani; Markus Sauer; Hans M. Maric; Davide Calebiro

doi:10.1038/s41467-022-35708-1

Nature Communications (Jan 2023)

Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane

Marie-Lise Jobin,
Sana Siddig,
Zsombor Koszegi,
Yann Lanoiselée,
Vladimir Khayenko,
Titiwat Sungkaworn,
Christian Werner,
Kerstin Seier,
Christin Misigaiski,
Giovanna Mantovani,
Markus Sauer,
Hans M. Maric,
Davide Calebiro

Affiliations

Marie-Lise Jobin: Institute for Pharmacology and Toxicology, University of Würzburg
Sana Siddig: Institute for Pharmacology and Toxicology, University of Würzburg
Zsombor Koszegi: Institute of Metabolism and Systems Research, University of Birmingham
Yann Lanoiselée: Institute of Metabolism and Systems Research, University of Birmingham
Vladimir Khayenko: Rudolf Virchow Center, Center for Integrative and Translational Bioimaging, University of Würzburg
Titiwat Sungkaworn: Institute for Pharmacology and Toxicology, University of Würzburg
Christian Werner: Department of Biotechnology and Biophysics, Biocenter, University of Würzburg
Kerstin Seier: Institute for Pharmacology and Toxicology, University of Würzburg
Christin Misigaiski: Institute for Pharmacology and Toxicology, University of Würzburg
Giovanna Mantovani: Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
Markus Sauer: Department of Biotechnology and Biophysics, Biocenter, University of Würzburg
Hans M. Maric: Rudolf Virchow Center, Center for Integrative and Translational Bioimaging, University of Würzburg
Davide Calebiro: Institute for Pharmacology and Toxicology, University of Würzburg

DOI: https://doi.org/10.1038/s41467-022-35708-1
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

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GABAB receptors mediate the effects of the main inhibitory neurotransmitter in the brain. Here, authors identify the cytoskeletal protein filamin A as a key player that controls the exact location and function of GABAB receptors at the cell surface.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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