Nature Communications (Aug 2016)
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
- Lesca M. Holdt,
- Anika Stahringer,
- Kristina Sass,
- Garwin Pichler,
- Nils A. Kulak,
- Wolfgang Wilfert,
- Alexander Kohlmaier,
- Andreas Herbst,
- Bernd H. Northoff,
- Alexandros Nicolaou,
- Gabor Gäbel,
- Frank Beutner,
- Markus Scholz,
- Joachim Thiery,
- Kiran Musunuru,
- Knut Krohn,
- Matthias Mann,
- Daniel Teupser
Affiliations
- Lesca M. Holdt
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Anika Stahringer
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Kristina Sass
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Garwin Pichler
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Nils A. Kulak
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Wolfgang Wilfert
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Alexander Kohlmaier
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Andreas Herbst
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Bernd H. Northoff
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Alexandros Nicolaou
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- Gabor Gäbel
- Department of Vascular and Endovascular Surgery, Ludwig-Maximilians-University Munich
- Frank Beutner
- LIFE—Leipzig Research Center for Civilization Diseases, Universität Leipzig
- Markus Scholz
- LIFE—Leipzig Research Center for Civilization Diseases, Universität Leipzig
- Joachim Thiery
- LIFE—Leipzig Research Center for Civilization Diseases, Universität Leipzig
- Kiran Musunuru
- Department of Medicine, Perelman School of Medicine at the University of Pennsylvania
- Knut Krohn
- LIFE—Leipzig Research Center for Civilization Diseases, Universität Leipzig
- Matthias Mann
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Daniel Teupser
- Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich
- DOI
- https://doi.org/10.1038/ncomms12429
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Circular RNAs are widely expressed in eukaryotic cells but their functions and mechanisms of action are still being elucidated. Here the authors show that circANRILmodulates rRNA maturation and confers protection again atherosclerosis.
