Nature Communications (Nov 2018)

Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

  • Toni Celià-Terrassa,
  • Caleb Bastian,
  • Daniel D. Liu,
  • Brian Ell,
  • Nicole M. Aiello,
  • Yong Wei,
  • Jose Zamalloa,
  • Andres M. Blanco,
  • Xiang Hang,
  • Dmitriy Kunisky,
  • Wenyang Li,
  • Elizabeth D. Williams,
  • Herschel Rabitz,
  • Yibin Kang

DOI
https://doi.org/10.1038/s41467-018-07538-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs negative feedback loop and enhances metastasis.