The Role and Application of Exosomes in Gastric and Colorectal Cancer

Qirong Li; Qirong Li; Dongxu Wang; Dayong Ding; Ye Feng; Ruizhi Hou; Dianfeng Liu; Chao Lin; Yongjian Gao

doi:10.3389/fphar.2021.825475

Frontiers in Pharmacology (Jan 2022)

The Role and Application of Exosomes in Gastric and Colorectal Cancer

Qirong Li,
Qirong Li,
Dongxu Wang,
Dayong Ding,
Ye Feng,
Ruizhi Hou,
Dianfeng Liu,
Chao Lin,
Yongjian Gao

Affiliations

Qirong Li: Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China
Qirong Li: Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China
Dongxu Wang: Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China
Dayong Ding: Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China
Ye Feng: Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China
Ruizhi Hou: Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China
Dianfeng Liu: Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China
Chao Lin: School of Grain Science and Technology, Jilin Business and Technology College, Changchun, China
Yongjian Gao: Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China

DOI: https://doi.org/10.3389/fphar.2021.825475
Journal volume & issue: Vol. 12

Abstract

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Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes—small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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Abstract

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