Transcriptome, proteomics and metabonomics in dermatology

Abstract

With the continuous emergence and breakthrough of new technologies and methods, the omics research has accelerated the development of high-throughput quantification. To reveal the mechanisms of disease in a comprehensive and multi-faceted manner, integration of one or more high-throughput omics technologies with bioinformatics has been used to analyze biological samples or data to reveal the link between biomolecules and their functions. Transcriptomics, proteomics, metabolomics and their combined analyses have made important contributions to the investigation of the etiology of skin diseases, differential and complementary diagnosis, discovery of biomarkers and novel therapeutic targets, as well as response to drug treatments. In the article, we review the applications of transcriptome, proteomics, metabonomics, and combined-analysis in dermatology.

Keywords

• multi-omics
• transcriptome
• proteomics
• metabonomics
• dermatology