Reproductive and Developmental Medicine (Jan 2017)

Spermatogonial Stem Cell Self - renewal and Differentiation

  • Li-Huan Cao,
  • Qiao-Li Zhang,
  • Xin-Hua Lin

DOI
https://doi.org/10.4103/2096-2924.224213
Journal volume & issue
Vol. 1, no. 3
pp. 171 – 178

Abstract

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Mammalian spermatogenesis is a complicated and precisely controlled process that requires spermatogonial stem cells (SSCs). SSCs maintain the stem cell pool, balance self-renewal–commitment with differentiation, and produce millions of sperm daily. Self-renewal and differentiation are controlled by intrinsic factors within SSCs and extrinsic factors from the “niche.” In this review, we discuss the biology of SSCs and the factors regulating their self-renewal and differentiation.

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