Nature Communications (Feb 2021)

Divergent rhodium-catalyzed electrochemical vinylic C–H annulation of acrylamides with alkynes

  • Yi-Kang Xing,
  • Xin-Ran Chen,
  • Qi-Liang Yang,
  • Shuo-Qing Zhang,
  • Hai-Ming Guo,
  • Xin Hong,
  • Tian-Sheng Mei

DOI
https://doi.org/10.1038/s41467-021-21190-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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α-Pyridones and α-pyrones are ubiquitous structural motifs found in natural products and components of biologically active small molecules. Here, the authors report an oxidant-free Rh-catalyzed electrochemical divergent vinylic C–H annulation of acrylamides with alkynes to α-pyridones and cyclic imidates.