Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes <i>Micromonospora</i> sp. HU138

Hui Zhang; Xiaohan Ren; Haiju Xu; Huan Qi; Shihua Du; Jun Huang; Ji Zhang; Jidong Wang

doi:10.3390/molecules28227672

Molecules (Nov 2023)

Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes <i>Micromonospora</i> sp. HU138

Hui Zhang,
Xiaohan Ren,
Haiju Xu,
Huan Qi,
Shihua Du,
Jun Huang,
Ji Zhang,
Jidong Wang

Affiliations

Hui Zhang: Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Xiaohan Ren: Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Haiju Xu: Key Laboratory of Horticultural Biotechnology of Taizhou, School of Agriculture and Bioengineering, Taizhou Vocational College of Science and Technology, Taizhou 318020, China
Huan Qi: Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Shihua Du: College of Plant Protection, Northeast Agricultural University, Harbin 150030, China
Jun Huang: Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Ji Zhang: College of Plant Protection, Northeast Agricultural University, Harbin 150030, China
Jidong Wang: Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China

DOI: https://doi.org/10.3390/molecules28227672
Journal volume & issue: Vol. 28, no. 22
p. 7672

Abstract

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Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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