Marshall Journal of Medicine (Apr 2018)

A Review of Mesenchymal Stem Cell Injections for Osteoarthritis

  • Ammar Qureshi,
  • Jill Goodwin,
  • Franklin D. Shuler,
  • Timothy Wilson-Byrne,
  • John J. Jasko,
  • Charles Giangarra

DOI
https://doi.org/10.18590/mjm.2018.vol4.iss2.10
Journal volume & issue
Vol. 4, no. 2
pp. 46 – 60

Abstract

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Mesenchymal stem cell (MSC) injections for osteoarthritis is reviewed. Methods- PubMed search identifying articles in English from 2003-2018 that used intra- articular injection (IA), cartilage repair, cartilage regeneration, chondral injury, adipose stem cells, bone marrow stem cells, mesenchymal stem cells, or autologous stem cells. Results – 388 patients receiving IA MSC injections are discussed with data obtained from 10 case reports or case series, 4 randomized clinical trials (RCT), 1 cohort study, and 3 case controlled therapeutic studies. Conclusions – MSC injections may be an effective adjunct in the management of osteoarthritis and a variety of cartilage related pathologies.

Keywords