HEPATOPROTECTIVE EFFECTS OF AQUEOUS AND METHANOLIC LEAVES EXTRACTS OF AZADIRACTA INDICA AGAINST CARBON TETRACHLORIDE (CCL4) INDUCED HEPATOTOXICITY IN WISTAR RATS

Abstract

Abstract The hepatoprotective effects of aqueous and methanolic leaf extracts of Azadirachta indica on carbon tetrachloride (CCl4) induced liver damage was determined in this study. Hepatoprotective effects of aqueous and methanolic leaf extracts of A. indica were determined by evaluating the liver function enzymes namely; Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total bilirubin (T. bil) and Alkaline phosphatase (ALP). Results showed weight gain in groups (I, III, IV, V, VI, and VII) and weight loss in group II. Significant (p < 0.05) increased in levels of AST, ALT, ALP, and T.BIL in CCl4-intoxicated rats were restored through normalization in aqueous and methanolic extracts’ treated rats in a dose-dependent manner. The aqueous extracts (150mg/kg body weight), methanolic leaf extracts (150mg/kg body weight) and silymarin (100mg/kg) showed potential hepatoprotective effects with a significant decrease (p < 0.05). The study suggests that aqueous and methanolic leaf treatments of A. indica has shown to be a potentially good human hepatoprotective medicinal plant at a higher dose of 150mg/kg body weight. Key words: Azadiracta indica, Hepatoprotective, Hepatotoxicity, Induced, Leaves extracts

Keywords

• azadiracta indica
• hepatoprotective
• hepatotoxicity
• ccl4-induced
• leaves extracts