Nature Communications (Jun 2022)
CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation
Abstract
Intestinal stem cells contribute to homeostasis through a balance between self-renewal and differentiation. Here the authors show that CCN1 is an intestinal stem cell niche factor that activates integrin αvβ3/αvβ5 signaling to regulate proliferation and differentiation through distinct downstream pathways.