Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination

Aloysious Ssemaganda; Huong Mai Nguyen; Faisal Nuhu; Naima Jahan; Catherine M. Card; Sandra Kiazyk; Giulia Severini; Yoav Keynan; Ruey-Chyi Su; Hezhao Ji; Bernard Abrenica; Paul J. McLaren; T. Blake Ball; Jared Bullard; Paul Van Caeseele; Derek Stein; Lyle R. McKinnon

doi:10.1038/s41467-022-30913-4

Nature Communications (Jun 2022)

Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination

Aloysious Ssemaganda,
Huong Mai Nguyen,
Faisal Nuhu,
Naima Jahan,
Catherine M. Card,
Sandra Kiazyk,
Giulia Severini,
Yoav Keynan,
Ruey-Chyi Su,
Hezhao Ji,
Bernard Abrenica,
Paul J. McLaren,
T. Blake Ball,
Jared Bullard,
Paul Van Caeseele,
Derek Stein,
Lyle R. McKinnon

Affiliations

Aloysious Ssemaganda: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Huong Mai Nguyen: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Faisal Nuhu: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Naima Jahan: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Catherine M. Card: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Sandra Kiazyk: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Giulia Severini: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Yoav Keynan: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Ruey-Chyi Su: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Hezhao Ji: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Bernard Abrenica: JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory, Public Health Agency of Canada
Paul J. McLaren: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
T. Blake Ball: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Jared Bullard: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Paul Van Caeseele: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Derek Stein: Department of Medical Microbiology and Infectious Diseases, University of Manitoba
Lyle R. McKinnon: Department of Medical Microbiology and Infectious Diseases, University of Manitoba

DOI: https://doi.org/10.1038/s41467-022-30913-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Whether mRNA SARS-CoV-2 vaccines promote T cells within the nasal mucosa of vaccine recipients is not known. Here the authors show that after mRNA SARS-CoV-2 vaccination, antigen specific T cells can be measured in the nasal mucosa and that these T cells may be localised to respond to a subsequent virus infection. Clinical trial registration NCT04713163

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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