Clinical evaluation of RNFL and GCC for diagnosis in early stage of chronic primary angle-closure glaucoma

Abstract

AIM:To explore the diagnosis value of retina nerve fiber layer(RNFL)and ganglion cell complex(GCC)in the early stage of chronic primary angle-closure glaucoma(CPACG), and investigate their relationship with mean defect(MD)of visual field.METHODS: Twenty-one patients with CPACG(38 eyes), 25 patients with suspected glaucoma(SG)(46 eyes)and 25 normal controls(49 eyes)were selected to perform SD-OCT. Statistical difference was analyzed the thickness of RNFL and GCC of average and all quadrants, and correlation between RNFL, GCC and MD of visual field. RESULTS:There were significant differences in average and all quadrant thickness of RNFL and GCC between CPACG group and control group(PPPPPr=0.65), GCC(r=0.72)in CPACG group. CONCLUSION:RNFL and GCC are useful to diagnose and monitor the early stage of CPACG, and GCC may be more significant for the disease.

Keywords

• OCT
• chronic primary angle-closure glaucoma
• retina nerve fiber layer
• ganglion cell complex
• mean visual field defect