Evaluation of anticancer properties of a new α-methylene-δ-lactone DL-249 on two cancer cell lines

Pomorska Dorota K.; Gach-Janczak Katarzyna; Jakubowski Rafał; Janecki Tomasz; Szymański Jacek; Janecka Anna

doi:10.1515/biol-2017-0021

Open Life Sciences (Jun 2017)

Evaluation of anticancer properties of a new α-methylene-δ-lactone DL-249 on two cancer cell lines

Pomorska Dorota K.,
Gach-Janczak Katarzyna,
Jakubowski Rafał,
Janecki Tomasz,
Szymański Jacek,
Janecka Anna

Affiliations

Pomorska Dorota K.: Department of Biomolecular Chemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland
Gach-Janczak Katarzyna: Department of Biomolecular Chemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland
Jakubowski Rafał: Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland
Janecki Tomasz: Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland
Szymański Jacek: Central Laboratory, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland
Janecka Anna: Department of Biomolecular Chemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland

DOI: https://doi.org/10.1515/biol-2017-0021
Journal volume & issue: Vol. 12, no. 1
pp. 178 – 189

Abstract

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The anticancer activity of a new synthetic α-methylene-δ-lactone DL-249 was reported in leukemia HL-60 and breast cancer MCF-7 cells and compared with the activity of a natural α-methylene-γ-lactone from Tanacetum parthenium, parthenolide.

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

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