Emerging Infectious Diseases (Jul 2010)

Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues

  • Yoshifumi Iwamaru,
  • Morikazu Imamura,
  • Yuichi Matsuura,
  • Kentaro Masujin,
  • Yoshihisa Shimizu,
  • Yujing Shu,
  • Megumi Kurachi,
  • Kazuo Kasai,
  • Yuichi Murayama,
  • Shigeo Fukuda,
  • Sadao Onoe,
  • Ken’ichi Hagiwara,
  • Yoshio Yamakawa,
  • Tetsutaro Sata,
  • Shirou Mohri,
  • Hiroyuki Okada,
  • Takashi Yokoyama

DOI
https://doi.org/10.3201/eid1607.091882
Journal volume & issue
Vol. 16, no. 7
pp. 1151 – 1154

Abstract

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We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.

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