Using Mice to Treat (Wo)men: Mining Genetic Changes in Patient Xenografts to Attack Breast Cancer

Steffi Oesterreich; Adam M. Brufsky; Nancy E. Davidson

doi:10.1016/j.celrep.2013.09.008

Cell Reports (Sep 2013)

Using Mice to Treat (Wo)men: Mining Genetic Changes in Patient Xenografts to Attack Breast Cancer

Steffi Oesterreich,
Adam M. Brufsky,
Nancy E. Davidson

Affiliations

Steffi Oesterreich: Women’s Cancer Research Center, University of Pittsburgh Cancer Institute and UPMC Cancer Center, Magee-Womens Hospital and Magee-Womens Research Institute, Departments of Pharmacology and Chemical Biology and Medicine, University of Pittsburgh, Pittsburgh 15213, USA
Adam M. Brufsky: Women’s Cancer Research Center, University of Pittsburgh Cancer Institute and UPMC Cancer Center, Magee-Womens Hospital and Magee-Womens Research Institute, Departments of Pharmacology and Chemical Biology and Medicine, University of Pittsburgh, Pittsburgh 15213, USA
Nancy E. Davidson: Women’s Cancer Research Center, University of Pittsburgh Cancer Institute and UPMC Cancer Center, Magee-Womens Hospital and Magee-Womens Research Institute, Departments of Pharmacology and Chemical Biology and Medicine, University of Pittsburgh, Pittsburgh 15213, USA

DOI: https://doi.org/10.1016/j.celrep.2013.09.008
Journal volume & issue: Vol. 4, no. 6
pp. 1061 – 1062

Abstract

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In this issue of Cell Reports, Li et al. show that the analysis of genetic changes in patient-derived xenografts can reveal crucial details of tumor evolution, such as the emergence of functional estrogen receptor mutations in endocrine-resistant breast cancer.

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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