Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Abstract

Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu Ionut Vasile,2 Cristian Onisor,7 Alexandru Nechifor2 1Dermatology Department, “Sf. Cuvioasa Parascheva” Clinical Hospital of Infectious Diseases, Galati, Romania; 2Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Galati, Romania; 3Multidisciplinary Integrated Center of Dermatological Interface Research (MIC-DIR) [Centrul Integrat Multi disciplinar de Cercetare de Interfata Dermatologica (CIM-CID)], Galați, Romania; 4Dermatology Department, Municipal Emergency Hospital, Timişoara, Romania; 5Neurology Department, Fundeni Clinical Institute, Bucharest, Romania; 6Neurology Department, “Bagdasar-Arseni” Emergency Clinical Hospital, Bucharest, Romania; 7Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galați, Romania; 8Pharmaceutical Sciences Department, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Galati, Romania; 9Dermatology Department, Center for the Morphologic Study of the Skin MORPHODERM, “Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania; 10Department of Dermatology, Allergology and Venereology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; 11Apolo Medical Center, Bucharest, Romania*These authors contributed equally to this workCorrespondence: Anca Arbune, Neurology Department, Fundeni Clinical Institute, 258 Fundeni Street, Bucharest, 022328, Romania, Tel [phone], Email [email protected] Elena Niculet, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galați, 35 Alexandru Ioan Cuza Street, Galați, 800008, Romania, Tel [phone], Email [email protected]: The interrelations and sequencing of interleukins are complex (inter)actions where each interleukin can stimulate the secretion of its preceding interleukin. In this paper, we attempt to summarize the currently known roles of IL-4, IL-13, IL-31, and IL-33 from a multi-disciplinary perspective. In order to conduct a comprehensive review of the current literature, a search was conducted using PubMed, Google Scholar, Medscape, UpToDate, and Key Elsevier for keywords. The results were compiled from case reports, case series, letters, and literature review papers, and analyzed by a panel of multi-disciplinary specialist physicians for relevance. Based on 173 results, we compiled the following review of interleukin signaling and its clinical significance across a multitude of medical specialties. Interleukins are at the bed rock of a multitude of pathologies across different organ systems and understanding their role will likely lead to novel treatments and better outcomes for our patients. New interleukins are being described, and the role of this inflammatory cascade is still coming to light. We hope this multi-discipline review on the role interleukins play in current pathology assists in this scope.Keywords: interleukin cascade, IL-4, IL-13, IL-31, IL-33

Keywords

• interleukin cascade
• il-4
• il-13
• il-31
• il-33;