Journal of Hematology & Oncology (Nov 2021)

Born to survive: how cancer cells resist CAR T cell therapy

  • Jean Lemoine,
  • Marco Ruella,
  • Roch Houot

DOI
https://doi.org/10.1186/s13045-021-01209-9
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

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Abstract Although chimeric antigen receptor T cells demonstrated remarkable efficacy in patients with chemo-resistant hematologic malignancies, a significant portion still resist or relapse. This immune evasion may be due to CAR T cells dysfunction, a hostile tumor microenvironment, or resistant cancer cells. Here, we review the intrinsic resistance mechanisms of cancer cells to CAR T cell therapy and potential strategies to circumvent them.

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