Nature Communications (Oct 2021)

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

  • Julie Massart,
  • Rasmus J. O. Sjögren,
  • Brendan Egan,
  • Christian Garde,
  • Magnus Lindgren,
  • Weifeng Gu,
  • Duarte M. S. Ferreira,
  • Mutsumi Katayama,
  • Jorge L. Ruas,
  • Romain Barrès,
  • Donal J. O’Gorman,
  • Juleen R. Zierath,
  • Anna Krook

DOI
https://doi.org/10.1038/s41467-021-26095-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Exercise induces structural and functional adaptations in skeletal muscle that involve transcriptomic remodeling, including of miRNA expression. Here the authors examine the expression of miRNAs in human muscle following exercise training and investigate the functions of miR-19b-3p on glucose metabolism in cells and mouse muscle.