Folia Histochemica et Cytobiologica (Jan 2012)

The prognostic significance of the immunohistochemical expression of P53 and BCL-2 in endometrial cancer

  • Lech Chyczewski,
  • Jacek Niklinski,
  • Magdalena Garbowicz,
  • Slawomir J. Terlikowski,
  • Bozena Dobrzycka,
  • Marek Kulikowski

DOI
https://doi.org/10.5603/14722
Journal volume & issue
Vol. 49, no. 4
pp. 631 – 635

Abstract

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The objective of this study was to verify the frequency of P53 and BCL-2 immunohistochemical expression in 98 patients with endometrial carcinoma, and to correlate it with clinical stage and patient survival. A significant difference was found regarding the frequency of P53 expression when comparing type I and II tumors (23.7% and 54.5%, respectively; p = 0.006). A positive correlation was observed between P53 immunoexpression and patient survival in type I and II tumors (p = 0.009 and p = 0.036, respectively). BCL-2 expression was significantly more frequent in early clinical stages in both types of endometrial cancer (p < 0.001 and 0.002) and correlated with a decrease in overall survival in type I endometrial cancer (p = 0.014). Thus, the prognostic value of these biomarkers in endometrial cancer needs to be further investigated. (<i>Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 631&#8211;635</i>)

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