Southern Clinics of Istanbul Eurasia (Jan 2019)
The Effect Of Chemotherapy On Malnutrition In Geriatric Group With Metastatic Colorectal Cancer
Abstract
INTRODUCTION[|]Malnutrition in geriatric colorectal (CRC) cancer patients, especially that received chemotherapy (CT), is a frequent condition. The aim of this study was to determine the effect of CT on malnutrition condition in patients with geriatric metastatic CRC (mCRC). [¤]METHODS[|]136 patients aged 70 and over with a diagnosis of mCRC were enrolled in the study. The nutritional status of the patients was evaluated with Nutritional risk Score-2002 (NRS-2002) before CT and after one course of CT.[¤]RESULTS[|]Median follow-up time is 18.5 months. Median age is 74. The ECOG performance score of all patients is 0 or 1. The 62.5% has liver metastasis, 26% has lung metastasis, 25% peritoneal metastasis, and 8% bone metastasis. It was determined that 17.3% of patients had malnutrition, and 24.6% had a risk of malnutrition. 49.4% of patients with pre-CT weight loss have begun. The average weight loss before the first CT is 12.1%, and the incidence of malnutrition after a one course of CT has been made to 46.4% (P = 0.001). [¤]DISCUSSION AND CONCLUSION[|]Malnutrition is frequently observed in patients with geriatric mCRC and even a single course of KT has increased malnutrition of the patients.[¤]
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