Sarcopenia, Osteoporosis and Its Complications

Abstract

Today, the significant attention of scientists is paid to the study of associative changes in muscle and bone tissue with age. The reduction of muscle mass and its function is associated with reduced bone mineral density, increased risk of falls, deterioration in the quality of life, functionality and increased patient mortality. However, there is a small number of studies that have examined the relationship between sarcopenia and osteoporotic fractures. The aim of research: to study the particularities of body composition, structural and functional state of bone in women aged 65 and older depending on the presence of vertebral deformations. We have examined 171 women aged 65–89 years. Depending on the presence of vertebral deformations, the patients were divided into two groups: A — 105 women without vertebral deformations, B — 66 women with vertebral deformations. Lean and fat masses, bone mineral density and trabecular bone score, lateral vertebral assessment were performed by dual X-ray absorptiometry (Prodigy, GEHC Lunar, Madison, WI, USA). We determined that patients with vertebral deformations as compared to the women without deformations had significantly lower indices of bone mineral density, trabecular bone score, lean and fat masses (p < 0.05). The incidence of presarcopenia (reduced lean mass) in women with vertebral deformations was 14.6 %, in women without vertebral deformations — 2.2 %.

Keywords

• muscle tissue
• lean mass
• bone mineral density
• osteoporosis
• vertebral deformations
• women