Journal of Gandhara Medical and Dental Sciences (Jul 2021)

Histopathological Study of Post-Surgical Gallbladder to Establish True Histopathology Proven Chronic Inflammation

  • Tania Khattak,
  • Almas Khattak,
  • Susan Kakakhel,
  • Anwar Ul Haque

DOI
https://doi.org/10.37762/jgmds.8-3.189
Journal volume & issue
Vol. 8, no. 3

Abstract

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OBJECTIVES: The aim of this study was to establish true histopathology proven diagnosis of chronic cholecystitis. METHODOLOGY: A cross-sectional study was conducted on 51 post-surgical gallbladders was done to assess their histopathological patterns in a single centered tertiary care hospital. The specimens were studied for chronic cholecystitis, fibrosis, hypertrophy and presence of Rokitansky-Aschoff sinuses. Descriptive analysis was done and associations of the histopathological changes with demographic data of patients were analyzed through Chi-squared test. RESULTS: Fifty-one post cholecystectomy samples of gallbladder were analyzed for histopathological changes with 82.4% showing chronic cholecystitis, 84.3% fibrosis, 64.7% congestion, and more than 60% mild or moderate hypertrophy. Moreover, 49% of the specimens showed Rokitansky-Aschoff sinuses. All these changes suggest chronic inflammation. CONCLUSION: Chronic cholecystitis, fibrosis, and Rokitansky-Aschoff sinuses are the most common histopathological findings in specimens of patients undergone cholecystectomy for cholelithiasis.

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