Expression and Significance of Serum DKK1 in Gastric Cancer Patients

ZHANG Rui; PENG Tao; YIN Jian; SONG Song; WANG Shen; MI Zihan; CHEN Wen; REN Jiansong

doi:10.3971/j.issn.1000-8578.2022.21.1212

Zhongliu Fangzhi Yanjiu (Jul 2022)

Expression and Significance of Serum DKK1 in Gastric Cancer Patients

ZHANG Rui,
PENG Tao,
YIN Jian,
SONG Song,
WANG Shen,
MI Zihan,
CHEN Wen,
REN Jiansong

Affiliations

ZHANG Rui: Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
PENG Tao: Department of Blood Transfusion, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
YIN Jian: Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
SONG Song: Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
WANG Shen: Department of Epidemiology, China Medical University, Shenyang 110122, China
MI Zihan: Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China
CHEN Wen: Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
REN Jiansong: Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

DOI: https://doi.org/10.3971/j.issn.1000-8578.2022.21.1212
Journal volume & issue: Vol. 49, no. 7
pp. 692 – 697

Abstract

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Objective To explore the expression and significance of serum DKK1 in patients with gastric cancer. Methods We selected 170 gastric cancer patients (gastric cancer group) and 170 subjects with non-gastric cancer during the same period (control group). ELISA was used to detect the DKK1 level. The ROC curve was used to evaluate the diagnostic performance, and we analyzed the relation between DKK1 level and age, gender, family history of gastric cancer, cigarette smoking, alcohol consumption, tumor size, TNM stage, infiltration depth, lymph node metastasis, liver metastasis, vascular invasion, perineural invasion. Results The serum DDK1 level in GC patients was higher than that in control group (P 0.05). However, DKK1 level was significantly related with TNM stage, infiltration depth, lymph node metastasis and perineural invasion (all P < 0.05). Conclusion Serum DKK1 level is higher in gastric cancer patients than that of control group and related with the severity of lesions, which indicates that serum DKK1 may be a potential biomarker for gastric cancer screening.

Published in Zhongliu Fangzhi Yanjiu

ISSN: 1000-8578 (Print)
Publisher: Magazine House of Cancer Research on Prevention and Treatment
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.zlfzyj.com

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