Nature Communications (Sep 2021)

A general approach to protein folding using thermostable exoshells

  • Samira Sadeghi,
  • Siddharth Deshpande,
  • Girish Vallerinteavide Mavelli,
  • Alphan Aksoyoglu,
  • Jayesh Bafna,
  • Mathias Winterhalter,
  • R. Manjunatha Kini,
  • David P. Lane,
  • Chester L. Drum

DOI
https://doi.org/10.1038/s41467-021-25996-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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In vitro protein folding can often result in aggregation and low yields. Here the authors use nanoscale exoshells to improve soluble yield, functional yield and specific activity of folded proteins.