Acta Scientiarum. Health Sciences (Aug 2017)

<b><i>In vitro</i> synergistic activity of lidocaine and miconazole against <i>Candida albicans

  • Maria da Conceição dos Santos Oliveira Cunha,
  • Tarcísio Paulo de Almeida Filho,
  • Francisco Afrânio Cunha,
  • Ana Gesselena da Silva Farias,
  • Ieda Pereira de Souza,
  • Everardo Albuquerque Menezes

DOI
https://doi.org/10.4025/actascihealthsci.v39i2.32413
Journal volume & issue
Vol. 39, no. 2

Abstract

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Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant.

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