BMJ Open (Nov 2019)
Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile
- Yuhuan Liu,
- Lei Zhang,
- Qing Liu,
- Hong Zhu,
- Ying Wang,
- Hong Huang,
- Min Jiang,
- Yi Zhang,
- Xiaojing Ma,
- Dingmei Wang,
- Yuang Jiang,
- Ying Ye,
- Mi Ji,
- Yalan Dou,
- Xiaotian Chen,
- Mengru Li,
- Wei Sheng,
- Guoying Huang,
- Weifen Luo,
- Yin Ye,
- Yumei Liu,
- Gu Qing(s),
- Gu Qing(o),
- Linmei Zhu,
- De’ai Hou,
- Peiyu Sun,
- Hongbing Wang,
- Li Meng,
- Zifen Dai,
- Li fen,
- Shufang Chen,
- Zhenhua Tang,
- Jiahao Wu,
- Shuhua Wang,
- Dan li,
- Yu Ke,
- Weiping Cao,
- Baoren Zhang,
- Nailing Wang,
- Qiumin Xia,
- Guoying Lao,
- HongMei Jin,
- Wenjuan Xie,
- Pin Yi,
- Weiming Gong,
- JianXin Xu,
- Yingying Qian,
- Mingjie Luo,
- Jingwei Xia,
- Dongmei Chen,
- Zhenyu Tang,
- Xuejing Zhu,
- Huiling Yang,
- Xiaotian Li,
- Zhiyong Wu,
- Chuanmin Ying,
- Shan Shi,
- Yanquan Zhang,
- Mingyi Yang,
- Xiaohua Zhang,
- Lin Guan,
- Jinyu Xu,
- Honglin Wang,
- Fang Shen,
- Wenying Li,
- Xiaojing Teng,
- Jinling Zhao,
- Cuili Zhu,
- Hongwei Chen,
- Xiaoming Yuan,
- Meihua Zhang,
- Yaqiong Jin,
- Qing Yang,
- Min Feng,
- Yan Wu,
- Sa Guo,
- Hongling Du,
- Zhanyue Yi,
- Renhua Shi,
- Qinfen Su,
- Yingying Lv,
- Yun Sun,
- Qiongpei Gu,
- Xixia Pang,
- Qingwu Zhang,
- Songxiao Bai,
- Baoqiao Qi
Affiliations
- Yuhuan Liu
- Lei Zhang
- Clinical Medical Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, People`s Republic of China
- Qing Liu
- Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden
- Hong Zhu
- Department of Oncology, Xiangya Hospital Central South University, Changsha, Hunan, China
- Ying Wang
- 1 Australian Institute of Health Innovation, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia
- Hong Huang
- Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China
- Min Jiang
- Department of Gastroenterology, The First Hospital of China Medical University, Shenyang city, Liaoning province, China
- Yi Zhang
- Department of Psychiatry, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA
- Xiaojing Ma
- 12 Cardiovascular Center, Children`s Hospital of Fudan University, National Children`s Medical Center, Shanghai, China
- Dingmei Wang
- Children’s Hospital of Fudan University, Shanghai, China
- Yuang Jiang
- Children’s Hospital of Fudan University, Shanghai, China
- Ying Ye
- 4 Anesthesiology and Perioperative Care Service, VA Palo Alto Health Care System, Palo Alto, California, USA
- Mi Ji
- Children’s Hospital of Fudan University, Shanghai, China
- Yalan Dou
- Department of Clinical Epidemiology, Children`s Hospital of Fudan University, National Children`s Medical Center, Shanghai, China
- Xiaotian Chen
- Department of Clinical Nutrition, Nanjing Drum Tower Hospital, Nanjing, China
- Mengru Li
- Children’s Hospital of Fudan University, Shanghai, China
- Wei Sheng
- Children’s Hospital of Fudan University, Shanghai, China
- Guoying Huang
- 12 Cardiovascular Center, Children`s Hospital of Fudan University, National Children`s Medical Center, Shanghai, China
- Weifen Luo
- Yin Ye
- Yumei Liu
- Gu Qing(s)
- Gu Qing(o)
- Linmei Zhu
- De’ai Hou
- Peiyu Sun
- Hongbing Wang
- Li Meng
- Zifen Dai
- Li fen
- 6The Second Xiangya Hospital of Central South University, Changsha, China
- Shufang Chen
- Zhenhua Tang
- Jiahao Wu
- International Peace Maternity and Child Health Hospital, Shanghai, China
- Shuhua Wang
- 1 Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia, USA
- Dan li
- Department of Neurology, Keshiketeng Banner Traditional Chinese Medicine Mongolian Medicine Hospitalorem Ipsum, Keshiketeng, Inner Mongolia, China
- Yu Ke
- Weiping Cao
- 1 Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
- Baoren Zhang
- Nailing Wang
- Qiumin Xia
- Guoying Lao
- HongMei Jin
- Wenjuan Xie
- Pin Yi
- Weiming Gong
- Institute of Sexually Transmitted Disease, Shanghai Skin Disease Hospital,School of Medicine, Tongji University, Shanghai,200443, China
- JianXin Xu
- Yingying Qian
- Mingjie Luo
- Jingwei Xia
- Shanghai Huangpu District Maternal and Child Health Care Institute, Shanghai, China
- Dongmei Chen
- Department of Neonatology, Quanzhou Maternity and Children’s Hospital, Quanzhou, Fujian Province, China
- Zhenyu Tang
- Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
- Xuejing Zhu
- Huiling Yang
- 3 Eastern-fusion Master Studio of Hezhou, Hezhou, China
- Xiaotian Li
- 3 Department of Obstetrics, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China
- Zhiyong Wu
- Department of Cardiology, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
- Chuanmin Ying
- Shan Shi
- Yanquan Zhang
- Mingyi Yang
- Xiaohua Zhang
- Department of Cardiology, Chengdu University of Traditional Chinese Medicine Affiliated Fifth Peoples Hospital, Chengdu, Sichuan, China
- Lin Guan
- 1 Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
- Jinyu Xu
- Honglin Wang
- Tianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People`s Republic of China
- Fang Shen
- Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
- Wenying Li
- Xiaojing Teng
- Jinling Zhao
- Cuili Zhu
- Hongwei Chen
- Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
- Xiaoming Yuan
- Meihua Zhang
- Yaqiong Jin
- Qing Yang
- Department of Nephrology, People`s Liberation Army Strategic Support Force Medical Center, Beijing, China
- Min Feng
- 1 Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
- Yan Wu
- Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
- Sa Guo
- Hongling Du
- Zhanyue Yi
- Renhua Shi
- Qinfen Su
- Yingying Lv
- Yun Sun
- 2 Department of Gynecology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, China
- Qiongpei Gu
- Xixia Pang
- Qingwu Zhang
- Songxiao Bai
- Baoqiao Qi
- DOI
- https://doi.org/10.1136/bmjopen-2019-031076
- Journal volume & issue
-
Vol. 9,
no. 11
Abstract
Purpose The Shanghai Preconception Cohort (SPCC) was initially established to investigate the associations of parental periconceptional nutritional factors with congenital heart disease (CHD) but has further analysed child growth and development and paediatric diseases.Participants Preparing-for-pregnancy couples who presented at Shanghai preconception examination clinics and early-pregnancy women before 14 gestational weeks were enrolled to comprise the periconceptional baseline study population. General characteristics, routine clinical data and consumption of diet supplements, such as folic acid and multivitamins, were collected. Blood samples were obtained at preconception and early, middle and late gestations using standard procedures. Multiple nutritional factors, including folate, homocysteine, vitamin A, vitamin D, vitamin E and metals, in the blood samples of participants selected using a case–control design were examined. Genomic DNA was extracted.Findings to date The baseline population included 8045 preconception couples, 3054 single women and 15 615 early-pregnancy women. Data from 12 402 births were collected, and follow-up of the cohort for other outcomes is ongoing. Currently, 151 cases of CHD were identified after birth. The pilot analysis in a small subgroup showed that approximately 20.0% of preconception women and 44.9% of early-pregnancy women had red blood cell (RBC) folate levels that met the international recommendation for preventing neural tube defects.Future plans Once a sufficient number of CHD cases are achieved, we will investigate the quantitative association of preconception RBC folate levels with CHD using a nested case–control design. The SPCC will be followed up for 18 years to investigate extensive outcomes of growth, development, obesity, and common and rare diseases during childhood and adolescence according to our plan. Blood nutritional factors will be examined in participants selected for specific aims. The SPCC will also allow for prospective cohort studies on extensive research questions.Trial registration number NCT 02737644
