Nature Communications (Oct 2020)
AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2
- Maria Paz Prada,
- Arsalan U. Syed,
- Gopireddy R. Reddy,
- Miguel Martín-Aragón Baudel,
- Víctor A. Flores-Tamez,
- Kent C. Sasse,
- Sean M. Ward,
- Padmini Sirish,
- Nipavan Chiamvimonvat,
- Peter Bartels,
- Eamonn J. Dickson,
- Johannes W. Hell,
- John D. Scott,
- Luis F. Santana,
- Yang K. Xiang,
- Manuel F. Navedo,
- Madeline Nieves-Cintrón
Affiliations
- Maria Paz Prada
- Department of Pharmacology, University of California Davis
- Arsalan U. Syed
- Department of Pharmacology, University of California Davis
- Gopireddy R. Reddy
- Department of Pharmacology, University of California Davis
- Miguel Martín-Aragón Baudel
- Department of Pharmacology, University of California Davis
- Víctor A. Flores-Tamez
- Department of Pharmacology, University of California Davis
- Kent C. Sasse
- Sasse Surgical Associates
- Sean M. Ward
- Department of Physiology and Cell Biology, University of Nevada Reno
- Padmini Sirish
- Department of Internal Medicine, University of California Davis
- Nipavan Chiamvimonvat
- Department of Pharmacology, University of California Davis
- Peter Bartels
- Department of Pharmacology, University of California Davis
- Eamonn J. Dickson
- Department of Physiology and Membrane Biology, University of California Davis
- Johannes W. Hell
- Department of Pharmacology, University of California Davis
- John D. Scott
- Department of Pharmacology, University of Washington Seattle
- Luis F. Santana
- Department of Physiology and Membrane Biology, University of California Davis
- Yang K. Xiang
- Department of Pharmacology, University of California Davis
- Manuel F. Navedo
- Department of Pharmacology, University of California Davis
- Madeline Nieves-Cintrón
- Department of Pharmacology, University of California Davis
- DOI
- https://doi.org/10.1038/s41467-020-18947-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Molecular mechanisms by which glucose modulates L-type Ca2+ channel activity and vascular reactivity are unclear. Here the authors report a nanocomplex orchestrated by AKAP5 that facilitates local purinergic stimulation of L-type Ca2+ channels and vasoconstriction during diabetic hyperglycemia.
