Extracellular vesicles as novel therapeutic targets and diagnosis markers

Yu Zhang; Weiliang Wu; Xiangbin Pan; Yanli Wang; Chengjie Wu; Lin Lu; Xi-Yong Yu; Yangxin Li

Extracellular Vesicle (Dec 2022)

Extracellular vesicles as novel therapeutic targets and diagnosis markers

Yu Zhang,
Weiliang Wu,
Xiangbin Pan,
Yanli Wang,
Chengjie Wu,
Lin Lu,
Xi-Yong Yu,
Yangxin Li

Affiliations

Yu Zhang: Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou Jiangsu 215123, PR China
Weiliang Wu: Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou Jiangsu 215123, PR China
Xiangbin Pan: Department of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, Key Laboratory of Cardiovascular Appratus Innovation, Beijing 100037, PR China
Yanli Wang: Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou Jiangsu 215123, PR China
Chengjie Wu: Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou Jiangsu 215123, PR China
Lin Lu: Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou Jiangsu 215123, PR China
Xi-Yong Yu: Key Laboratory of Molecular Target & Clinical Pharmacology and the NMPA & State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong 511436, PR China
Yangxin Li: Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou Jiangsu 215123, PR China; Corresponding author.

Journal volume & issue: Vol. 1
p. 100017

Abstract

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Extracellular vesicles (EVs) are membranous vesicles secreted from cells to the outside and are widely present in body fluids. The most commonly used method to isolate EVs is ultracentrifugation. EVs contain lipids, proteins, genetic material, and organelles, which can be used as communication carriers between different cells and potential disease biomarkers. EVs secreted by different cells (cancer cells, adipocytes, mesenchymal stem cells, immune cells et al.) play different functions. With the development of technology, EVs can also be engineered to deliver drugs. EVs also play an important role in the progression, prevention, diagnosis, and treatment of Corona Virus Disease 2019 (COVID-19).

Published in Extracellular Vesicle

ISSN: 2773-0417 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Biology (General); Medicine: Medicine (General)
Website: https://www.sciencedirect.com/journal/extracellular-vesicle

About the journal

Abstract

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