Nature Communications (Feb 2023)

A paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea

  • Marie-Claire Daugeron,
  • Sophia Missoury,
  • Violette Da Cunha,
  • Noureddine Lazar,
  • Bruno Collinet,
  • Herman van Tilbeurgh,
  • Tamara Basta

DOI
https://doi.org/10.1038/s41467-023-36210-y
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 14

Abstract

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Many eukaryotic and archaeal tRNAs carry a modified adenosine (t6A) that is synthesized by the KEOPS complex, which is composed of four subunits. A fifth subunit (Gon7) is found only in fungi and metazoa. Here the authors show that archaea also possess a fifth subunit, which is structurally and functionally similar to eukaryotic Gon7.