Curcumin suppresses cell viability in breast cancer cell line by affecting the expression of miR-15a-5p

Suer Ilknur; Abuaisha Asmaa; Kaya Murat; Abanoz Fahrunnisa; Cefle Kivanc; Palanduz Sukru; Ozturk Sukru

doi:10.1515/tjb-2024-0031

Türk Biyokimya Dergisi (Sep 2024)

Curcumin suppresses cell viability in breast cancer cell line by affecting the expression of miR-15a-5p

Suer Ilknur,
Abuaisha Asmaa,
Kaya Murat,
Abanoz Fahrunnisa,
Cefle Kivanc,
Palanduz Sukru,
Ozturk Sukru

Affiliations

Suer Ilknur: Department of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul, Türkiye
Abuaisha Asmaa: Department of Genetics, Institute of Health Sciences, Istanbul University, Istanbul, Türkiye
Kaya Murat: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye
Abanoz Fahrunnisa: Department of Genetics, Institute of Health Sciences, Istanbul University, Istanbul, Türkiye
Cefle Kivanc: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye
Palanduz Sukru: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye
Ozturk Sukru: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye

DOI: https://doi.org/10.1515/tjb-2024-0031
Journal volume & issue: Vol. 49, no. 5
pp. 656 – 665

Abstract

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Curcumin plays a leading role as an epigenetic regulator in cancer. miR-15a-5p is a crucial non-coding RNA for breast cancer (BRCA) and various cancers due to its tumor suppressor role. In our study, we aimed to examine the curcumin/miR-15a-5p/target gene interaction in BRCA cells.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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