Nature Communications (Oct 2022)
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
- Vikash Chandra,
- Hazem Ibrahim,
- Clémentine Halliez,
- Rashmi B. Prasad,
- Federica Vecchio,
- Om Prakash Dwivedi,
- Jouni Kvist,
- Diego Balboa,
- Jonna Saarimäki-Vire,
- Hossam Montaser,
- Tom Barsby,
- Väinö Lithovius,
- Isabella Artner,
- Swetha Gopalakrishnan,
- Leif Groop,
- Roberto Mallone,
- Decio L. Eizirik,
- Timo Otonkoski
Affiliations
- Vikash Chandra
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Hazem Ibrahim
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Clémentine Halliez
- Université Paris Cité, Institut Cochin, CNRS, INSERM
- Rashmi B. Prasad
- Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, CRC
- Federica Vecchio
- Université Paris Cité, Institut Cochin, CNRS, INSERM
- Om Prakash Dwivedi
- Institute for Molecular Medicine Finland (FIMM), Helsinki University
- Jouni Kvist
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Diego Balboa
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Jonna Saarimäki-Vire
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Hossam Montaser
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Tom Barsby
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Väinö Lithovius
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Isabella Artner
- Endocrine Cell Differentiation and Function group, Stem Cell Center, Lund University
- Swetha Gopalakrishnan
- Institute of Biotechnology, HiLIFE, University of Helsinki
- Leif Groop
- Institute for Molecular Medicine Finland (FIMM), Helsinki University
- Roberto Mallone
- Université Paris Cité, Institut Cochin, CNRS, INSERM
- Decio L. Eizirik
- ULB Center for Diabètes Research, Université Libre de Bruxelles
- Timo Otonkoski
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-022-34069-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8+ T-cell cytotoxicity; representing a potent therapeutic target to halt T1D progression.
